BRGSF™ mice




This new HIS mouse model is engineered in the (BALB/c Rag2tm1Fwa IL-2Rγ tm1Cgn SIRPαNOD) strain by eliminating the Flk2/Flt3 receptor (BRGSF). BRGSF mice harbored a defective mouse DC compartment and enhanced human DC development could be selectively achieved after hHSC engraftment and administration of exogenous human Flt3L. This novel HIS-DC model based on BRGSF mice should find multiple applications in the study of human DC biology and for screening of novel immunomodulators and vaccine candidates.