BRGS™ mice are excellent recipients for human hematopoietic cells. AXENIS routinely generates BRGS™ mice humanized for the immune system (HIS), using human CD34+ hematopoietic progenitor cells. These BRGS™-HIS mice contain all major human hematopoietic cell subsets, such as B cells, T cells (including CD4+ Treg cells), NK cells, dendritic cells and monocytes/macrophages – among others.
AXENIS already proposes optimized formats of BRGS™-HIS mice to address specific applications:
• BRGS™-DC – boosted for human dendritic cell content;
• BRGS™-ImStim – for robust immune responses;
• BRGS™-NK – boosted for human NK cell content;